Our First Title

Forthcoming 2026

Pourquoi ma sœur? Français ¿Por Qué Mi Hermana? Español Por Que a Minha Irmã? Português Why My Sister? English Warum Meine Schwester? Deutsch Perché Mia Sorella? Italiano 为什么是我妹妹? 中文 なぜ妹だったのか 日本語

Why My Sister? · ¿Por Qué Mi Hermana? · Por Que a Minha Irmã?
Mais pourquoi ma sœur ? · Warum Meine Schwester? · Perché Mia Sorella?
为什么是我妹妹? · なぜ妹だったのか

Eugenia was beautiful. Religious. Married young to a promising doctor in the north of Mexico. Five children came: four of them would go on to remarkable careers. Then the symptoms began, and the family she had built learned to live around a mother who was not always reachable.

Paty was her youngest daughter. A model. Strikingly pretty, brilliant, loved by everyone. She painted flowers in every color. Then the flowers lost their shape. Then the voices grew louder. Then it all changed.

What does it do to a family when the same genes, the same childhood, the same kitchen table produce four full lives and one life unmade? Why My Sister? is the answer a scientist spent thirty years trying to find, and never quite did. It is the story of a family that lives across two countries, two languages, two cultures, and now across two registers of the mind, the one we call well and the one we call ill.

That is where the local becomes universal. Every family has its silences. Every family has its question no one is allowed to ask out loud. This book asks it, and it asks it everywhere at once.

In 2026, Why My Sister? will be published in six major languages across two launch phases, with two additional Asian editions in development. The first phase brings English, Spanish, Portuguese, and French simultaneously to the Western Hemisphere, reaching 99% of the Americas in a language its readers call their own: more than 1.3 billion people from Nunavut to Patagonia.

The second phase brings German, the largest book market in continental Europe, and Italian, the fourth largest in the European Union. Together the six editions reach roughly 600 million European readers and, through the Lusophone reach into Africa and the Francophone geographies that stretch from Quebec to Dakar to Beirut to Noumea and Tahiti, nearly 3 billion readers worldwide. More than one third of humanity.

Beyond the six European-language editions, Chinese and Japanese editions are in development, with informational sites already live at wms-zh.com and wms-ja.com. Allele Books is actively seeking publishing partners in China and Japan. With both Asian editions added, the book's potential reach climbs from nearly 3 billion to more than 4.5 billion readers — over half of humanity.

consuelowalssbass.com

Get notified when the book launches

Keep Scrolling

First, the voices of colleagues. Beneath them waits the book itself: the family, the photographs, the scenes, the sentences that stay. Keep scrolling. It is worth it.

Voices on the Book

What specialists are saying

"Dr. Walss-Bass has written an extraordinary book, a one of a kind intimate voyage through the reality of schizophrenia — the cancer of mental illness — how it starts long before anyone knows it is coming, how it robs an individual of life, how it devastates family, friends and communities and also how science is trying to figure it all out. It is an unforgettable and highly informative read."

Daniel R. Weinberger, M.D.

Director and CEO, Lieber Institute for Brain Development · Professor of Psychiatry, Neurology, Neuroscience and Genetic Medicine, Johns Hopkins University School of Medicine

"In this blend of memoir and science, neuroscientist Consuelo Walss-Bass traces her Mexican American family's multigenerational struggle with schizophrenia and her own search for meaning and hope in the face of an illness that is still not well understood. As she hunts for biological answers in her lab, she discovers a different kind of truth in the family bonds that managed to survive madness, shame, and migration. A must-read for the tens of millions of people who have a loved one with serious mental illness."

Ronald C. Kessler, Ph.D.

McNeil Family Professor, Department of Health Care Policy, Harvard Medical School

"Dr. Walss-Bass weaves her inspiring personal story together with a clear and authoritative account of the latest scientific advances. She describes the huge challenges faced by those with schizophrenia and their families and the complex scientific picture that is emerging. But ultimately this is a story of hope — hope that with the right support, advocacy and treatment people with schizophrenia can live healthy and mostly happy lives, and hope that science is bringing us closer to better treatments."

Prof. Sir Mike Owen

Centre for Neuropsychiatric Genetics and Genomics, Cardiff University · Chair of the Schizophrenia Research Fund

"Dr. Consuelo Walss-Bass has created a completely engaging depiction of the truly familial dimensions of mental illness. This courageous personal account is both exceptionally readable and deeply affecting, forging an awareness of the breadth of the devastation that accompanies mental disorders. Lying alongside this portrayal of shared anguish, however, there is an appreciation of the remarkable strength of family members that provides a path of remarkable resilience that shapes the hope for the next generation."

Michael Meaney, Ph.D.

Professor, Douglas Hospital, Department of Psychiatry, McGill University

"This compassionate first-hand account by a psychiatric geneticist about the complications of family life with a mother and sister diagnosed with schizophrenia is illuminating about lived family experience. Relevant science is interspersed throughout the book and it is brought together in the epilogue, whose theme is asking why her sister inherited her mother's schizophrenia but not any of the four siblings."

Robert Plomin, Ph.D., CBE, FBA, FMedSci

Professor of Behavioral Genetics, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London

"This sensitive and courageous description of the evolution of mental illness across generations in a family beautifully weaves story-telling and instruction. Dr. Walss-Bass regales the reader with stories from her own family while explicating them with scientifically accurate descriptions of psychopathology. As an extra treat, she includes moving, lovely family pictures that further bring the narrative to life. You will learn, but you may weep."

Maria A. Oquendo, M.D., Ph.D.

Ruth Meltzer Professor and Chair of Psychiatry, Perelman School of Medicine, University of Pennsylvania · Psychiatrist-in-Chief, Hospital of the University of Pennsylvania

"This book about the personal story of a family through the lenses of the author who is a family member and a leading scientific researcher is a gift to both persons suffering from severe mental illness and their loved ones, and to the field. It importantly ends with a message of authentic hope derived from the research advances of the author and her expert view of the advances on the horizon."

Hilary P. Blumberg, M.D.

The John and Hope Furth Professor of Psychiatric Neuroscience; Professor of Psychiatry, Radiology & Biomedical Imaging, and the Child Study Center; Director, Mood Disorders Research Program, Yale School of Medicine

"A poignant history of multiple generations of two inter-woven families struggling to cope with individuals affected with schizophrenia. This book powerfully demonstrates what most psychiatric clinicians caring for the severely mentally ill already know — that the suffering of individuals with schizophrenia is not experienced only by the patients themselves but by their entire family system."

Kenneth S. Kendler, M.D.

Virginia Commonwealth University Department of Psychiatry

Now the Book

A mother in Torreón. A father who stayed. Five children. One sister. The photographs the family kept. The scenes the author could not leave out. What follows is not a summary. It is the book, in fragments.

The image that will not let go

"Paty, the younger sister, sitting on the edge of her bed at five in the morning in her freshly pressed school uniform, refusing to lie down so as not to wrinkle it. Chelo watches from the doorway and says nothing. She knows, without yet knowing that she knows, that something in her sister is breaking in a way no doctor in Torreón will be able to repair. And then the book begins."

on Why My Sister?

100+
Publications on the genetics of psychiatric disease
175+
Brains donated to her UTHealth Houston research collection
99%
Of the Western Hemisphere reached in a language they read as their own
1
Question that shaped a life, a family, and a science

Not a book
with translations
to follow.

Why My Sister? launches in 2026 in six major languages across two phases. The first phase brings English, Spanish, Portuguese, and French simultaneously to the Western Hemisphere, reaching 1.3 billion readers, 99% of the Americas, in a language they read as their own. The German and Italian editions follow, extending the book to roughly 600 million European readers and, through Lusophone Africa, Francophone geographies across four continents, and the working language of educated humanity, nearly 3 billion readers worldwide.

Beyond Europe and the Americas, Chinese and Japanese editions are in development, with informational sites already live at wms-zh.com and wms-ja.com. Allele Books is actively seeking publishing partners in China and Japan. With both Asian editions added, the book's potential reach climbs from nearly 3 billion to more than 4.5 billion readers — over half of humanity.

Not a book with translations added later. Six editions conceived together, with two more on the way, all belonging to the same moment, all belonging to the world.

"Llega a México como si siempre hubiera sido nuestro, porque en el fondo lo es." — It arrives in Mexico as if it were always ours, because at heart it is. — A Mexican Review

About the Book

Part memoir.
Part science.
All truth.

Why My Sister? traces the Walss family across generations and borders — from a young medical student watching patients in flowing white gowns at a hilltop sanatorium in Puebla, Mexico, to a Houston laboratory where skin cells are transformed into miniature brains.

At its center: five siblings, the same genes, the same chaotic childhood with a mother lost to psychosis. Four went on to distinguished careers. One — Paty, brilliant and beloved — drew flowers that slowly morphed into shapeless blobs as her cognition crumbled. She now lives in Chelo's garage apartment, stabilized on clozapine after years of chaos.

"É memória e é ciência. É confissão e é investigação. É, acima de tudo, uma pergunta que dói."

It is memory and science. Confession and investigation. Above all, a question that hurts. — Brazilian review

Walss-Bass weaves FKBP5 polymorphisms and iPSC-derived neurons together with searingly intimate family history — a childhood defined by silence, resilience, and the slow realization that something in her family could not be outrun.

Structure

Four movements
toward an answer
that doesn't exist.

Part I

The Mother

Beautiful, religious, unstable, frightening. The night she walked into the dark with the baby and said nothing.

Part II

The Siblings

Five children forged by the same fire. A father brilliant and absent. The scattered years before everything changed.

Part III

The Sister

Paty. The same dice. A different result. The question that became a career and a life's work.

Epilogue

The Science

Thirty years of progress — and the uncomfortable truth that the struggles have not really changed.

The Walss family
The Walss family · Brownsville, Texas. Rodolfo is seated center; Chelo is next to him.

From the book

"I started writing this book during the year of COVID isolation. My father had moved in with us, and for the first time in my life, we really talked. Learning about my parents' history gave me a new understanding of my own life." · · ·

The Walss-Bass family, early years

The rest belongs to the book.

From the Pages

Scenes that will
not let go

Real moments. Real family. A lifetime compressed into a question.

Part I · The Mother

Torreón, Mexico, late 1970s

Chelo opened her eyes and there was Paty — sitting cross-legged on the rug, in front of her bed, all dressed up in her brand-new uniform. "Is it time yet?" "No! Go back to sleep." Paty refused to get in bed for fear of wrinkling it. Chelo knew her sister would still be sitting in the same spot in a few hours when she woke up. She instinctively knew that Paty needed her.

Chapter 6 · Back to the Roots

Part I · The Mother

Ohio, mid-1970s

They walked down long, seemingly interminable dark corridors, women in strange gowns all around. Some mumbled to themselves. Others were wailing. Finally, a small, barely illuminated room. Just a bed and a nightstand. Mami was lying in it. They ran to her, but something was not right. She barely smiled. She did not hug them back as they all put their arms around her.

Chapter 5 · The Pendulum Swings

Part II · The Siblings

Torreón, Mexico, late 1980s

She remembered the day they flew to Mexico. Walking in the airport behind her mother, dressed in slim tight black pants and a red leather jacket, she thought her mother looked stunning, and she was sure she caught some people casting furtive glances at her. It seemed that Eugenia enjoyed the attention.

Chapter 8 · Everyone is on Their Own

Eugenia Aurioles & Rodolfo Walss · Wedding Portrait
Eugenia Aurioles & Rodolfo Walss · Wedding Portrait
Part I · The Mother

They were young, beautiful, and in love. The family they would build together would be large, loud, and full of life. No one could have known what was coming.

Torreón, Mexico · 1960s
Part II · The Siblings

Torreón, Mexico, late 1980s

"Don't you know? He is dead! Dead!" Chelo erupted in a loud wail. Her friend drove immediately to the funeral home. Sure enough, Jenny was already there, sitting on a chair, staring blankly at a wall, surrounded by people. Chelo pushed through them, kneeling at her feet, and buried her head in Jenny's lap, crying uncontrollably. Jenny was not crying. She consoled Chelo. "Don't worry, Chelito, we're going to be fine."

5
Siblings. Same genes. Same mother. Same impossible childhood.
1
Got the perfect storm. The rest spent their lives asking why.
Part III · The Sister

Airport, en route to Orlando

Just as a kettle at its boiling point starts hissing loudly, she started screaming obscenities, her voice getting louder and louder. Leo and Chelo were stunned. They had never seen Paty act this way. Everyone was staring. Eugenia, mortified, started mumbling to herself. The loudspeaker announced that boarding was now in progress.

Chapter 12 · Unraveling

Part III · The Sister

San Antonio, early 2000s

Her favorite thing to paint was flowers, in all kinds of shapes and colors. Her gradual cognitive decline could be traced from her paintings, over the span of a few months. The flowers slowly started to become amorphous, until they were just blots of color. Then the voices became louder. The psychosis was soon out of control.

Chapter 15 · Prodigal Daughter

The Great Pyramid of Cholula with the Iglesia de Nuestra Señora de los Remedios
The Great Pyramid of Cholula · Iglesia de Nuestra Señora de los Remedios · Puebla, Mexico
Paty · Torreón, Mexico, early 1990s
Paty · Torreón, Mexico · Early 1990s
Part III · The Sister

They called her the pretty one. She was a model and she was brilliant.
The illness did not care.

She was beloved. She was radiant. She married the love of her life.
The illness did not care.

Paty and Isaac on their wedding day
Paty and Isaac · The Wedding Day
Part III · The Sister

Brownsville, Texas

"My name is Isaac. I am married to your daughter Paty." Rodolfo felt a strange mixture of relief and disbelief. She is ok. She is married? Then: "She has been diagnosed with schizophrenia." Rodolfo started to cry, not caring that he was still on the phone. He had dreaded this moment. He had hoped against hope it would never come to pass.

Chapter 15 · Prodigal Daughter

Part III · The Sister

Houston, 2016

Dan's soothing voice pacified her. The officers were gentle, well trained for this. Paty offered no further resistance — but as she was getting into the van, her last words to Chelo were: "I will never forgive you for this!"

Chapter 17 · Breakthroughs

Part III · The Sister

Houston, Texas, 2025

Being around her sister is hard for Chelo. She loses patience often and is easily irritated when Paty asks the same questions repeatedly or does not follow simple instructions. It is as if she sees her mother in her. Feelings of anger, helplessness, and distressing memories, memories she tries hard to repress, swell up to the surface. She knows there is no rational explanation for this; it is not her sister's fault. But she cannot help it.

Chapter 18 · Two Sides of a Coin

Eugenia Aurioles · Torreón, Mexico, circa 1953
Eugenia Aurioles · Torreón, Mexico, circa 1953
Part I · The Mother

Eugenia

Everything in this book begins with her. A girl on a street in Torreón in 1953, holding her father's hand. The wife he stood by despite everything. The mother they loved was the same mother they feared. She brought inside her the question they could never stop asking.

Torreón, Mexico · circa 1953
Epilogue · The Science

Houston, Now

Science Rooted in Family

"I now worry about my own children. I have done my best to reduce their stress levels since they were babies. I know this is all I can do. The genetics are there. But maybe I can do something about controlling their environment. The question remains: Why her? The struggles remain. The fight continues. But hope endures."

The Walss-Bass family

The Walss-Bass family

20+
Years of research into the biology of schizophrenia. Still no definitive answer. Still asking.
1
Book that holds both the science and the grief without flinching at either.

These are fragments only. The story belongs to the book.

Get notified when the book launches

Critical Response

Reviews from across the Western Hemisphere: USA, Mexico, and Brazil

🇺🇸 English

"What makes this book truly extraordinary is Chelo's refusal to separate the scientist from the sister. It is not a narrative device. It is a form of intellectual honesty. It is Chelo saying: I needed to understand in order to survive." — A work that transcends its own genre.

Why My Sister? · Advance Review

🇲🇽 Spanish

"El libro que escribió no es un libro de ciencia. Es un libro sobre la culpa de haber sido salvada. Chelo no se enfermó. Paty sí. La misma madre. El mismo padre. La misma infancia en el norte de México. Los mismos dados. Distinto resultado." — México no debería dejarlo pasar.

A Mexican Review · ¿Por Qué Mi Hermana?

🇧🇷 Portuguese

"A escrita tem a contenção de quem aprendeu desde criança a não chamar atenção, e é justamente essa contenção que torna certas cenas insuportavelmente belas. A mãe saindo de madrugada com o bebê nos braços sem dizer para onde vai. A irmã sentada imóvel na cama, de uniforme novo, recusando-se a deitar para não amarrotá-lo." — E então você não consegue parar de ler.

A Brazilian Review · Por Que a Minha Irmã?

A Brazilian Review · In Full · Translated into English

Part of what makes us human is our persistent need to understand things that refuse to be understood. Schizophrenia is one of those things. It has resisted explanation for as long as medicine has had a name for it. What Consuelo Walss-Bass has done, in this quiet and devastating book, is refuse to accept that resistance as an answer.

Why My Sister? arrives as one of those rare books that cannot be easily classified. It is memory and it is science. It is confession and investigation. It is, above all, a question that hurts.

Consuelo Walss-Bass, known all her life as Chelo, grew up in Torreón, in northern Mexico, in a family marked by a presence no one knew how to name. Her mother, Eugenia, was beautiful, religious, unstable, and frightening. Her father, Rodolfo, was a physician, ambitious, contradictory, and absent in the way certain men are absent even when they are standing in the same room. Five children grew up in that environment of fractured affection, learning early that survival required silence, shrewdness, and the ability to leave the scene at the right moment.

Chelo was the quiet one. While her older sister Jenny excelled at everything she touched and her brother Rudy disappeared into the streets, she stayed in the library. She observed. She accumulated questions. And she carried, without yet having words for it, the intuition that something very serious was about to happen to the youngest sister, Paty, born on a November night in 1974.

The question of the title is not rhetorical. It is the question that structures an entire life. Why Paty, and not her? Why did schizophrenia choose that specific sister, in a family where so many other risk factors were present for everyone? Science, Chelo explains with the authority of someone who has spent decades in neurogenetics, does not answer with names. It answers with probabilities, with combinations of genetic variants, with the statistical cruelty of knowing that environment and DNA conspire together against certain people from before birth.

What makes this book truly extraordinary is Chelo's refusal to separate the scientist from the sister. In every chapter that recounts the turbulent childhood in Torreón, the hospitalizations of Eugenia, the slow unraveling of Paty in adulthood, the crises that erupted in San Antonio, she weaves in rigorous explanations of epigenetics, early stress, antipsychotic pharmacology, and the still-immense limits of what medicine knows about this disease. It is not a narrative device. It is a form of intellectual honesty. It is Chelo saying: I needed to understand in order to survive.

The writing has the restraint of someone who learned from childhood not to draw attention to herself, and it is precisely that restraint that makes certain scenes unbearably beautiful. The mother leaving at dawn with the baby in her arms without saying where she is going. The sister sitting motionless on the bed in her new school uniform, refusing to lie down so as not to wrinkle it. Paty as an adult, already in full psychosis, her face distorted into an expression Chelo had never seen on her before.

For readers across Latin America, there is an additional dimension to this book. The Walss-Bass family lived between Mexico and the United States carrying everything that Latin Americans carry when they cross that border: the stigma of difference, the shame of mental illness, religiosity as both shield and trap, and the ancient difficulty of asking for help when raised to believe that family problems stay inside the house.

The sad truth, however, is that medicine still cannot say why Paty and not Chelo. Only the passage of time will reveal the distance between our current ideas of causation and the concrete reality. What this book offers is not easy consolation, nor a tidy redemption. It offers something more valuable: the honest company of someone who also does not know the answer, but decided it was worth spending an entire life asking the right questions.

The Aurioles family, Torreón, Mexico
The Aurioles family · Torreón, Mexico, circa 1960. Eugenia is standing in the back row, in the floral dress.
Paty's 50th birthday, Houston, Texas
Paty's 50th birthday · Torreón, Mexico.
Eugenia is seated at right, in the brown jacket, next to Paty in the red sweater.
Consuelo Walss-Bass, PhD

Photo by Shyam Tailor

The Author

Consuelo
Walss-Bass, PhD

Consuelo Walss-Bass grew up in Torreón, Mexico, where she dreamed of becoming a biochemist. No such degree existed in her hometown, and no local company would hire a woman engineer, so she crossed the border to San Antonio with a suitcase and a stubborn sense of purpose. She never went back.

Today she is Professor and the John S. Dunn Foundation Distinguished Chair in the Department of Psychiatry and Behavioral Sciences at McGovern Medical School, UTHealth Houston. She directs the Psychiatric Genetics Program and the UTHealth Houston Brain Collection for Research in Psychiatric Disorders, a resource she founded in 2014 that has received donations from over 175 individuals.

Her most treasured possession is her mind. Her greatest fear is one she has never stopped studying. Her greatest achievement is that her sister Paty is stable.

Fellow, ACNP 100+ Publications Continuous NIH Funding Wellcome Leap Awardee NAMI Scientist of the Year UTHealth Houston
Eugenia as a child in Torreón, 1950; her daughter Consuelo Walss-Bass in her lab at UTHealth Houston, 75 years later
Chelo searches for the answers Eugenia could never have known to ask. Top: Eugenia Aurioles (left) holding her father's hand, with her brother, sister, and mother · Torreón, Mexico, circa 1950. Bottom: Seventy-five years later, Eugenia's daughter Consuelo (Chelo) Walss-Bass studies at UTHealth Houston the biology of the condition that shaped their family. Bottom photo credit: Houston Chronicle/Hearst Newspapers through Getty Images.

The Science Behind the Story

She didn't just ask why.
She built the tools
to find out.

The central challenge of psychiatric research is access. You cannot biopsy a living person's brain. And when you examine a deceased brain, you cannot see how its cells once communicated. The Walss-Bass laboratory attacks this problem from both directions.

Walss-Bass directs the Psychiatric Genetics Program at McGovern Medical School, UTHealth Houston, and holds the John S. Dunn Foundation Distinguished Chair in the Department of Psychiatry and Behavioral Sciences. Her research sits at the intersection of genomics, epigenomics, transcriptomics, and cellular neuroscience — a multi-omics approach unified by a single question: what makes certain individuals vulnerable to developing psychiatric disorders when others, carrying the same genes and raised in the same environment, are spared?

Her work is funded by concurrent NIH R01 grants and spans schizophrenia, bipolar disorder and suicide, substance use disorders, HIV neuropathogenesis, and cocaine addiction genetics across international cohorts. She has testified before the Texas legislature on mental health policy and has served on numerous NIH study sections.

Walss-Bass is also a co-author of a landmark consensus report by the International Society of Psychiatric Genetics, published in the American Journal of Medical Genetics Part B: Neuropsychiatric Genetics in 2025, that establishes a framework for equitable collaboration between researchers in high-income and low- and middle-income countries. The report addresses the problem of "helicopter research," scientists from wealthy nations collecting data in poorer ones without reciprocity, and proposes concrete strategies for capacity building, fair data sharing, and authorship parity across the planning, implementation, and dissemination stages of global psychiatric genetics research. Her own decade-long cocaine addiction genetics collaboration in Brazil, funded through the Fogarty International Center (R01 DA044859), is a working example of the principles the report advocates.

The Foundation

The UTHealth Houston
Brain Collection

In 2014, Walss-Bass founded the UTHealth Houston Brain Collection for Research in Psychiatric Disorders, in close collaboration with the Harris County Institute of Forensic Sciences. Every morning, a research coordinator visits the medical examiner's office to identify potential donors. Each brain is paired with blood, skin biopsies, toxicology reports, and detailed clinical and behavioral information gathered through family interviews and medical records. This represents a novel psychological autopsy process that gives each specimen a human context no tissue bank number could convey.

The collection has received donations from over 175 individuals with conditions including schizophrenia, bipolar disorder, substance use disorders, and major depression, alongside control donors with no psychiatric diagnosis. It has become a platform not only for her own laboratory but for collaborating investigators across the country, enabling single-cell RNA sequencing of epigenetic mechanisms regulating HIV latency in the CNS (R01 MH134392, with Rice), postmortem transcriptomic dissection of anterior insula and subgenual cingulate circuitry in bipolar disorder and suicide (R01 MH134791, with Jabbi), and genome-wide association studies of cocaine use disorder across a 2,000-subject cohort in Rio Grande do Sul, Brazil (R01 DA044859, with Schmitz), an international collaboration that Walss-Bass co-initiated a decade ago.

The methodological thread running through all of it is multi-omics: genomics, epigenomics, transcriptomics, proteomics. The material foundation is always the brain collection. And the question behind every grant, every sequencing run, every morning visit to the medical examiner's office, is the same one behind the book.

The Living Window

From Skin Cells
to Miniature Brains

You cannot biopsy a living person's brain. But you can grow one from their skin. Using gene reprogramming, based on the Nobel Prize-winning discovery that mature cells can be converted back into stem cells, Walss-Bass's lab transforms donated skin cells into induced pluripotent stem cells (iPSCs), then differentiates them into neurons, astrocytes, and three-dimensional brain organoids smaller than a pea.

These miniature brains carry the same DNA as the donor. Her lab was among the first to identify signaling alterations in iPSC-derived neurons from patients with schizophrenia, using skin cells from affected siblings in Costa Rica to demonstrate subtle differences in how their neurons communicated. The organoid work allows researchers to study how genetic variants alter neuronal migration, synaptic formation, and development in real time, something postmortem tissue alone could never reveal.

Her most recent major publication, in Genomic Psychiatry, used brain-specific epigenetic clocks to show for the first time that alcohol, opioids, and stimulants each accelerate biological aging of the brain through distinct molecular pathways. This work was covered by Italy's Corriere della Sera and science outlets worldwide. The tissue came from the brain collection. The question behind the science was the same one behind the book.

Active NIH Research Portfolio

R01 MH134392 HIV-1 CNS Latency & Neuropathogenesis Single-cell RNA sequencing of lncRNAs, mRNAs, and miRNAs in human autopsy brain specimens. Investigating epigenetic mechanisms of active and latent HIV infection in the brain. Control specimens from the UTHealth Brain Collection. With Rice · NIMH
R01 MH134791 Bipolar Disorder & Suicide Postmortem RNA-sequencing of anterior insula and subgenual anterior cingulate circuitry. Bulk tissue and single-nucleus approaches to map molecular dysregulations in bipolar disorder suicide. Brain collection tissue. With Jabbi · NIMH
R01 DA044859 Cocaine Use Disorder · Brazil Population-based genetic epidemiology in Rio Grande do Sul: 1,000 CUD subjects, 1,000 controls. Genome-wide associations, traumatic stress and DNA methylation, HIV infection effects on epigenetics. Fogarty International Center collaboration co-initiated in 2014. With Schmitz · NIDA / Fogarty

Research in the News